Humanwell Pharmaceutical US, Inc.
Principal / Senior Principal Biologist or Pharmacologist in Drug Discovery
Humanwell Pharmaceutical US, Inc., Discovery-Spring Garden, Maryland, United States
Key Responsibilities
Provide
strategic leadership
in biology and pharmacology across pain and CNS drug discovery programs. Identify and validate novel targets, and design assays related to functional signal transduction pathways relevant to CNS and pain. Design, conduct, and oversee
in vitro and in vivo efficacy, PK/PD, and mechanistic studies
in relevant CNS disease models (e.g., pain, neurodegeneration, psychiatric disorders). Develop, refine, and validate
translational models
to enhance predictive value in preclinical studies. Integrate pharmacology/biology findings with medicinal chemistry, DMPK, biomarkers, toxicology, and clinical input to drive candidate progression. Collaborate closely with regulatory teams to prepare
IND submission packages
and support regulatory interactions. Work with medical professionals to contribute to clinical trial protocol development. Manage CROs, external collaborations, and internal laboratory operations to ensure high-quality, reproducible science. Mentor and supervise junior scientists to build a strong and sustainable research team. Present strategy, progress, and results to project leadership, senior management, and external partners. Qualifications
Ph.D. (or equivalent degree) in
Biology, Cell Biology, Pharmacology, Neuroscience, Physiology , or a related biomedical discipline. 10+ years of industrial experience
in pharmaceutical/biotech R&D, with significant depth in CNS or pain drug discovery. Demonstrated expertise
in vitro assay development
and/or
in vivo CNS pharmacology
(behavioral assays, imaging, surgical models, transgenic platforms). Proven success in
advancing molecules into IND-enabling studies . Strong knowledge of
PK/PD principles, biomarker development, and translational pharmacology . Experience managing
cross-functional teams, CROs, and external collaborators . Ability to work independently and collaboratively in a fast-paced, dynamic environment. Familiarity with
regulatory guidelines
for preclinical and clinical research. Excellent communication skills; ability to communicate in both
English and Chinese
is preferred. Preferred Attributes
Familiarity with modern CNS technologies and translation platforms. Track record of
patents, publications, and/or clinical candidate nominations . Experience contributing to
regulatory packages and IND submissions . Exposure across multiple therapeutic areas, with primary focus in CNS. Medical education or teaching experience is a plus. Why Join Us?
This is a unique opportunity to lead and innovate in a collaborative, fast-paced environment. You will play a pivotal role in shaping our CNS biology and pharmacology strategy, advancing our pipeline, and translating cutting-edge science into transformative therapies for patients. We offer a
competitive salary and benefits package , including health insurance, 401K, and a vacation plan. Our company is committed to
Diversity and Inclusion , and we welcome candidates of all backgrounds to apply. If you are interested in this position, please submit your resume and a cover letter highlighting your relevant experience and qualifications.
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Provide
strategic leadership
in biology and pharmacology across pain and CNS drug discovery programs. Identify and validate novel targets, and design assays related to functional signal transduction pathways relevant to CNS and pain. Design, conduct, and oversee
in vitro and in vivo efficacy, PK/PD, and mechanistic studies
in relevant CNS disease models (e.g., pain, neurodegeneration, psychiatric disorders). Develop, refine, and validate
translational models
to enhance predictive value in preclinical studies. Integrate pharmacology/biology findings with medicinal chemistry, DMPK, biomarkers, toxicology, and clinical input to drive candidate progression. Collaborate closely with regulatory teams to prepare
IND submission packages
and support regulatory interactions. Work with medical professionals to contribute to clinical trial protocol development. Manage CROs, external collaborations, and internal laboratory operations to ensure high-quality, reproducible science. Mentor and supervise junior scientists to build a strong and sustainable research team. Present strategy, progress, and results to project leadership, senior management, and external partners. Qualifications
Ph.D. (or equivalent degree) in
Biology, Cell Biology, Pharmacology, Neuroscience, Physiology , or a related biomedical discipline. 10+ years of industrial experience
in pharmaceutical/biotech R&D, with significant depth in CNS or pain drug discovery. Demonstrated expertise
in vitro assay development
and/or
in vivo CNS pharmacology
(behavioral assays, imaging, surgical models, transgenic platforms). Proven success in
advancing molecules into IND-enabling studies . Strong knowledge of
PK/PD principles, biomarker development, and translational pharmacology . Experience managing
cross-functional teams, CROs, and external collaborators . Ability to work independently and collaboratively in a fast-paced, dynamic environment. Familiarity with
regulatory guidelines
for preclinical and clinical research. Excellent communication skills; ability to communicate in both
English and Chinese
is preferred. Preferred Attributes
Familiarity with modern CNS technologies and translation platforms. Track record of
patents, publications, and/or clinical candidate nominations . Experience contributing to
regulatory packages and IND submissions . Exposure across multiple therapeutic areas, with primary focus in CNS. Medical education or teaching experience is a plus. Why Join Us?
This is a unique opportunity to lead and innovate in a collaborative, fast-paced environment. You will play a pivotal role in shaping our CNS biology and pharmacology strategy, advancing our pipeline, and translating cutting-edge science into transformative therapies for patients. We offer a
competitive salary and benefits package , including health insurance, 401K, and a vacation plan. Our company is committed to
Diversity and Inclusion , and we welcome candidates of all backgrounds to apply. If you are interested in this position, please submit your resume and a cover letter highlighting your relevant experience and qualifications.
#J-18808-Ljbffr