Septerna
Director/Senior Director, In Vivo Pharmacology
Septerna, South San Francisco, California, us, 94083
Overview
Septerna is a biotechnology company based in South San Francisco, CA pursuing life-changing medicines with a GPCR-focused approach. The Native Complex Platform recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context to enable access to modern structural and screening technologies for drug discovery across the GPCR class. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth. We are expanding our multidisciplinary team of individuals focused on creating revolutionary medicines to address unmet patient needs. Septerna embraces diversity of thought, expertise, and background through collaboration. Join a team of drug hunters, scientists, and professionals to contribute your passion, creativity, and energy to our mission. We pursue ground-breaking innovations and foster an environment where employees succeed by learning from each other and working as a team. We are committed to developing meaningful therapeutics for patients with high unmet need. This is an opportunity to work with talented individuals on the frontlines of therapeutic discovery and development, moving therapies through preclinical research toward the clinic. The successful candidate will contribute their passion and expertise to a dynamic team focused on discovering disease-modifying therapeutics for patients in a fast-paced environment. Responsibilities
Lead the design, execution, and interpretation of in vivo efficacy, mechanism-of-action, and PK/PD studies in animal models of disease Develop and refine animal models that reflect human disease pathophysiology across multiple therapeutic areas Provide scientific and strategic leadership for a team of in vivo pharmacologists and research associates Engage in critical experiments with scientific and technical guidance on surgical procedures, phenotypic assessments, and data interpretation Collaborate cross-functionally with discovery biology, DMPK, chemistry, toxicology, and clinical pharmacology to advance compounds from discovery through IND-enabling studies Oversee vivarium operations, ensuring compliance with IACUC protocols and regulatory standards Support dose selection and prediction of clinical outcomes through studies Manage external CRO relationships and academic collaborations Author and review preclinical study reports and regulatory submissions (IB, IND) Serve as project team leader or in vivo pharmacology representative on drug discovery teams, contributing to program strategy and decision-making Qualifications
PhD in Pharmacology, Physiology, or related life sciences with 10+ years of industry experience in in vivo pharmacology and drug development Experience across multiple therapeutic areas (e.g., endocrine, inflammation, metabolic, CNS) preferred Proven track record in people management, leading in vivo pharmacology teams and cross-functional project teams in biopharmaceutical settings Experience managing CRO relationships and external collaborations Extensive hands-on experience with animal disease models, experimental design, and translational science Strong background in PK/PD principles and data interpretation Experience contributing to regulatory filings and understanding regulatory expectations for nonclinical studies Excellent leadership, mentoring, communication, and interpersonal skills The anticipated salary range for candidates who will work in South San Francisco, CA is $250,000 - $270,000. Individual pay may vary based on job-related skills, experience, location, and education. Septerna's compensation package includes benefits, stock options, and an annual target bonus for full-time positions. We are an Equal Opportunity employer and will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
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Septerna is a biotechnology company based in South San Francisco, CA pursuing life-changing medicines with a GPCR-focused approach. The Native Complex Platform recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context to enable access to modern structural and screening technologies for drug discovery across the GPCR class. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth. We are expanding our multidisciplinary team of individuals focused on creating revolutionary medicines to address unmet patient needs. Septerna embraces diversity of thought, expertise, and background through collaboration. Join a team of drug hunters, scientists, and professionals to contribute your passion, creativity, and energy to our mission. We pursue ground-breaking innovations and foster an environment where employees succeed by learning from each other and working as a team. We are committed to developing meaningful therapeutics for patients with high unmet need. This is an opportunity to work with talented individuals on the frontlines of therapeutic discovery and development, moving therapies through preclinical research toward the clinic. The successful candidate will contribute their passion and expertise to a dynamic team focused on discovering disease-modifying therapeutics for patients in a fast-paced environment. Responsibilities
Lead the design, execution, and interpretation of in vivo efficacy, mechanism-of-action, and PK/PD studies in animal models of disease Develop and refine animal models that reflect human disease pathophysiology across multiple therapeutic areas Provide scientific and strategic leadership for a team of in vivo pharmacologists and research associates Engage in critical experiments with scientific and technical guidance on surgical procedures, phenotypic assessments, and data interpretation Collaborate cross-functionally with discovery biology, DMPK, chemistry, toxicology, and clinical pharmacology to advance compounds from discovery through IND-enabling studies Oversee vivarium operations, ensuring compliance with IACUC protocols and regulatory standards Support dose selection and prediction of clinical outcomes through studies Manage external CRO relationships and academic collaborations Author and review preclinical study reports and regulatory submissions (IB, IND) Serve as project team leader or in vivo pharmacology representative on drug discovery teams, contributing to program strategy and decision-making Qualifications
PhD in Pharmacology, Physiology, or related life sciences with 10+ years of industry experience in in vivo pharmacology and drug development Experience across multiple therapeutic areas (e.g., endocrine, inflammation, metabolic, CNS) preferred Proven track record in people management, leading in vivo pharmacology teams and cross-functional project teams in biopharmaceutical settings Experience managing CRO relationships and external collaborations Extensive hands-on experience with animal disease models, experimental design, and translational science Strong background in PK/PD principles and data interpretation Experience contributing to regulatory filings and understanding regulatory expectations for nonclinical studies Excellent leadership, mentoring, communication, and interpersonal skills The anticipated salary range for candidates who will work in South San Francisco, CA is $250,000 - $270,000. Individual pay may vary based on job-related skills, experience, location, and education. Septerna's compensation package includes benefits, stock options, and an annual target bonus for full-time positions. We are an Equal Opportunity employer and will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
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