TalentCraft
We are seeking an experienced scientist in ADME/PK to join our growing research team. This role is crucial for driving the in vitro and in vivo evaluation of our therapeutic candidates, with a focus on understanding the pharmacokinetics, metabolism, bioavailability and optimal dosing regimen for novel compounds. The ideal candidate will have a deep understanding of ADME/PK principles in drug discovery and experience with DMPK testing in animal models. This hands‑on role will require working in the lab, as well as designing studies to help guide company strategy as it relates to advancement of our drug discovery pipeline.
Key Responsibilities
Independently design and conduct studies (both internally and externally via CRO’s) to assess the ADME properties ( A bsorption,
D istribution,
M etabolism,
E xcretion, and
P harmacokinetics) and bioavailability of drug candidates using various in vitro and animal models.
Develop detailed experimental protocols and manage the review/approval process with IACUC
Work closely with interdisciplinary teams, including medicinal chemists and biologists, to integrate DMPK data into the broader drug discovery and development process.
Work collaboratively with Bioanalytics and in vivo Biology team on design, execution, and data analysis.
Required Skills and Experience
M.S. or Ph.D. in Bioanalytic Chemistry, Analytical Chemistry, or related field
M.S. with 10+ years or Ph.D. with 4+ years in ADME/PK
Strong expertise in preclinical pharmacokinetic studies, including hands‑on design, execution, and analysis of animal experiments
Experience with appropriate data analysis/statistical software for PK/PD modeling
Proven track record of scientific contributions, such as publications in peer‑reviewed journals
Excellent problem‑solving skills and the ability to work independently as well as part of a multidisciplinary team
Strong communication skills, both written and verbal, with the ability to effectively present complex data
Preferred Skills and Experience
Industry experience in drug discovery setting
Expertise with LC/MS-MS and other high‑throughput analytical methods for the quantitative analysis of biological samples in complex matrices (e.g., plasma, tissue, cell lysates)
Experience with a variety of sample preparation techniques for large molecule therapeutics including SPE, IEX, HIC
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Key Responsibilities
Independently design and conduct studies (both internally and externally via CRO’s) to assess the ADME properties ( A bsorption,
D istribution,
M etabolism,
E xcretion, and
P harmacokinetics) and bioavailability of drug candidates using various in vitro and animal models.
Develop detailed experimental protocols and manage the review/approval process with IACUC
Work closely with interdisciplinary teams, including medicinal chemists and biologists, to integrate DMPK data into the broader drug discovery and development process.
Work collaboratively with Bioanalytics and in vivo Biology team on design, execution, and data analysis.
Required Skills and Experience
M.S. or Ph.D. in Bioanalytic Chemistry, Analytical Chemistry, or related field
M.S. with 10+ years or Ph.D. with 4+ years in ADME/PK
Strong expertise in preclinical pharmacokinetic studies, including hands‑on design, execution, and analysis of animal experiments
Experience with appropriate data analysis/statistical software for PK/PD modeling
Proven track record of scientific contributions, such as publications in peer‑reviewed journals
Excellent problem‑solving skills and the ability to work independently as well as part of a multidisciplinary team
Strong communication skills, both written and verbal, with the ability to effectively present complex data
Preferred Skills and Experience
Industry experience in drug discovery setting
Expertise with LC/MS-MS and other high‑throughput analytical methods for the quantitative analysis of biological samples in complex matrices (e.g., plasma, tissue, cell lysates)
Experience with a variety of sample preparation techniques for large molecule therapeutics including SPE, IEX, HIC
#J-18808-Ljbffr