Climb Bio
Vice President, Program Leader
About Climb:
Climb Bio is a clinical-stage biotechnology company developing therapeutics for patients with immune-mediated diseases. Our product candidates include budoprutug, an anti-CD19 monoclonal antibody that presents us with an exciting opportunity given its broad potential applicability across a number of B-cell mediated diseases, including systemic lupus erythematosus, immune thrombocytopenia, and membranous nephropathy and CLYM116, an anti-APRIL monoclonal antibody in preclinical development for IgA nephropathy.
At Climb Bio, our team has a knack for seeing what no one else sees—and a drive to achieve results no one expects. We are seeking an experienced Vice President to serve as the Program Lead for Climb’s lead asset, budoprutug. Reporting to the Chief Medical Officer, this individual will be accountable for developing and executing integrated development plans that drive the program from development through registration and commercialization. The Vice President, Program Leader will provide strategic leadership, ensure alignment with company goals, and serve as a key driver of cross-functional collaboration and decision making.
Key Responsibilities:
Lead the strategic and operational planning for the company’s lead asset, guiding the program through Phase 2 and into late-stage development.
Develop and maintain integrated development plans that incorporate clinical, regulatory, CMC, preclinical, and commercial considerations to optimize the probability of success.
Define and articulate the long‑term strategy for registration, ensuring regulatory pathways, clinical endpoints, and evidence packages are aligned with health authority expectations and future market needs.
Partner with clinical and commercial colleagues to evaluate indication expansion opportunities, guiding indication prioritization and selection to maximize the value of the asset.
Serve as the central point of accountability for program execution, monitoring progress, anticipating risks, and driving proactive mitigation strategies.
Partner with regulatory and clinical leadership to plan and support interactions with global health authorities, including preparation for pivotal trials, regulatory submissions, and registration.
Ensure program objectives remain aligned with corporate strategy, investor expectations, and long‑range planning.
Provide high‑quality program updates, strategic options, and recommendations to executive leadership and the Board of Directors.
Build strong relationships across clinical, regulatory, CMC, commercial, and finance to ensure cross‑functional alignment and readiness for registration and launch.
Cultivate a culture of accountability, collaboration, and scientific rigor across the program team.
Qualifications:
Advanced degree in life sciences (MD, PhD, PharmD, or equivalent) strongly preferred.
15+ years of experience in biotech or pharmaceutical drug development, with a track record of advancing assets through mid‑ and late‑stage clinical development toward registration.
Experience in Immunology & Inflammation and biologics/antibody drug development preferred.
Deep understanding of clinical development strategy, regulatory interactions, and product lifecycle management from early development through registration.
Experience preparing for pivotal trials, regulatory submissions, and successful interactions with FDA and/or EMA.
Strong strategic thinker with the ability to anticipate challenges, weigh options, and translate vision into executable plans.
Demonstrated success leading cross‑functional program teams in small or emerging biotech environments.
Exceptional leadership, communication, and influencing skills with the ability to engage stakeholders at all levels.
This position will be based out of our Wellesley, MA office. Base salary offered may vary depending on the individual’s skills, experience, and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, Life & Disability, 401k company match, generous paid time off, and equity.
Qualified candidates are encouraged to forward their resumes to careers@climbbio.com.
Climb is a publicly traded company. For more information, please visit climbbio.com.
Climb is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
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At Climb Bio, our team has a knack for seeing what no one else sees—and a drive to achieve results no one expects. We are seeking an experienced Vice President to serve as the Program Lead for Climb’s lead asset, budoprutug. Reporting to the Chief Medical Officer, this individual will be accountable for developing and executing integrated development plans that drive the program from development through registration and commercialization. The Vice President, Program Leader will provide strategic leadership, ensure alignment with company goals, and serve as a key driver of cross-functional collaboration and decision making.
Key Responsibilities:
Lead the strategic and operational planning for the company’s lead asset, guiding the program through Phase 2 and into late-stage development.
Develop and maintain integrated development plans that incorporate clinical, regulatory, CMC, preclinical, and commercial considerations to optimize the probability of success.
Define and articulate the long‑term strategy for registration, ensuring regulatory pathways, clinical endpoints, and evidence packages are aligned with health authority expectations and future market needs.
Partner with clinical and commercial colleagues to evaluate indication expansion opportunities, guiding indication prioritization and selection to maximize the value of the asset.
Serve as the central point of accountability for program execution, monitoring progress, anticipating risks, and driving proactive mitigation strategies.
Partner with regulatory and clinical leadership to plan and support interactions with global health authorities, including preparation for pivotal trials, regulatory submissions, and registration.
Ensure program objectives remain aligned with corporate strategy, investor expectations, and long‑range planning.
Provide high‑quality program updates, strategic options, and recommendations to executive leadership and the Board of Directors.
Build strong relationships across clinical, regulatory, CMC, commercial, and finance to ensure cross‑functional alignment and readiness for registration and launch.
Cultivate a culture of accountability, collaboration, and scientific rigor across the program team.
Qualifications:
Advanced degree in life sciences (MD, PhD, PharmD, or equivalent) strongly preferred.
15+ years of experience in biotech or pharmaceutical drug development, with a track record of advancing assets through mid‑ and late‑stage clinical development toward registration.
Experience in Immunology & Inflammation and biologics/antibody drug development preferred.
Deep understanding of clinical development strategy, regulatory interactions, and product lifecycle management from early development through registration.
Experience preparing for pivotal trials, regulatory submissions, and successful interactions with FDA and/or EMA.
Strong strategic thinker with the ability to anticipate challenges, weigh options, and translate vision into executable plans.
Demonstrated success leading cross‑functional program teams in small or emerging biotech environments.
Exceptional leadership, communication, and influencing skills with the ability to engage stakeholders at all levels.
This position will be based out of our Wellesley, MA office. Base salary offered may vary depending on the individual’s skills, experience, and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, Life & Disability, 401k company match, generous paid time off, and equity.
Qualified candidates are encouraged to forward their resumes to careers@climbbio.com.
Climb is a publicly traded company. For more information, please visit climbbio.com.
Climb is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
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