University of California, San Francisco
Marshall Lab – Junior/Assistant Specialist
University of California, San Francisco, San Francisco, California, United States, 94199
Marshall Lab – Junior/Assistant Specialist
Department:
Biochemistry and Biophysics, UC San Francisco
Location:
San Francisco, CA
Overview Carry out experimental research on the role of chromatin modifications in single‑cell regeneration in the giant ciliate Stentor. How cells are able to form and regenerate pattern within themselves is a big open question in cell biology, and the unicellular organism Stentor provides a unique opportunity to address this question due to its ability to regenerate after physical perturbation. Although we know that gene expression programs underlie much of regeneration, we do not know how the genes are regulated. Given the role of chromatin modification in controlling important regulatory pathways in other organisms, combined with prior data on nuclear shape changes during regeneration, we expect to see alteration in histone modification during the regeneration process. This position will involve carrying out experiments to test this possibility.
Responsibilities Conduct experimental work to test the role of chromatin modifications in Stentor regeneration, including designing and performing assays, analyzing data, and interpreting results to advance understanding of the underlying mechanisms.
Required Qualifications
Baccalaureate degree (or equivalent) or at least four years of research experience for Junior rank.
Master’s degree (or equivalent) or a baccalaureate degree with three or more years of research experience for Assistant rank.
Preferred Qualifications
Prior experience with protein biochemistry methods in Stentor, specifically cell lysis, gel electrophoresis, and Western blot analysis of Stentor proteins.
Prior experience working with Stentor including culturing and manipulating the cells.
Knowledge of histone modifications and experience with using histone modification‑specific antibodies as probes for modification state.
Salary Range $55,000–$70,700.
Application Instructions Please apply online at https://aprecruit.ucsf.edu/JPF05897 with a cover letter, CV, and contact information for two references. Applicant materials must list current and/or pending qualifications upon submission. The selected candidate must meet all of the qualifications at the time of appointment.
Document Requirements
Cover Letter
Curriculum Vitae (CV must clearly list current and/or pending qualifications e.g., board eligibility/certification, medical licensure, etc.).
Statement of Research (Optional)
Reference Requirements
2 required (contact information only)
Compliance As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.
As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.
Equal Employment Opportunity The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.
UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.
San Francisco, CA
#J-18808-Ljbffr
Biochemistry and Biophysics, UC San Francisco
Location:
San Francisco, CA
Overview Carry out experimental research on the role of chromatin modifications in single‑cell regeneration in the giant ciliate Stentor. How cells are able to form and regenerate pattern within themselves is a big open question in cell biology, and the unicellular organism Stentor provides a unique opportunity to address this question due to its ability to regenerate after physical perturbation. Although we know that gene expression programs underlie much of regeneration, we do not know how the genes are regulated. Given the role of chromatin modification in controlling important regulatory pathways in other organisms, combined with prior data on nuclear shape changes during regeneration, we expect to see alteration in histone modification during the regeneration process. This position will involve carrying out experiments to test this possibility.
Responsibilities Conduct experimental work to test the role of chromatin modifications in Stentor regeneration, including designing and performing assays, analyzing data, and interpreting results to advance understanding of the underlying mechanisms.
Required Qualifications
Baccalaureate degree (or equivalent) or at least four years of research experience for Junior rank.
Master’s degree (or equivalent) or a baccalaureate degree with three or more years of research experience for Assistant rank.
Preferred Qualifications
Prior experience with protein biochemistry methods in Stentor, specifically cell lysis, gel electrophoresis, and Western blot analysis of Stentor proteins.
Prior experience working with Stentor including culturing and manipulating the cells.
Knowledge of histone modifications and experience with using histone modification‑specific antibodies as probes for modification state.
Salary Range $55,000–$70,700.
Application Instructions Please apply online at https://aprecruit.ucsf.edu/JPF05897 with a cover letter, CV, and contact information for two references. Applicant materials must list current and/or pending qualifications upon submission. The selected candidate must meet all of the qualifications at the time of appointment.
Document Requirements
Cover Letter
Curriculum Vitae (CV must clearly list current and/or pending qualifications e.g., board eligibility/certification, medical licensure, etc.).
Statement of Research (Optional)
Reference Requirements
2 required (contact information only)
Compliance As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.
As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.
Equal Employment Opportunity The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.
UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.
San Francisco, CA
#J-18808-Ljbffr