Senior Scientist I, Protein Biochemistry/Enzymology

Join to apply for the Senior Scientist I, Protein Biochemistry/Enzymology role at Revolution Medicines

Revolution Medicines is a clinical‑stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity

• Design, develop, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and enable hit finding and validation efforts.
• Perform kinetic studies to support a deep understanding of small molecules with complex mechanisms of action, including covalent and non‑covalent molecular glue inhibitors and activators.
• Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities.
• Support cross‑functional teams to generate novel insights and drive drug discovery and development.
• Effectively communicate findings to diverse audiences through presentations, reports, and publications.

Required Skills, Experience and Education

• Ph.D. in Biochemistry, Enzymology, Chemical Biology, or a related field with 5–8 years of experience, preferably in an industrial setting.
• Thorough understanding of enzyme kinetics and the ability to design, analyze, and interpret experimental results.
• Hands‑on experience handling recombinant proteins and analyzing activity through experimental assays (fluorescence, absorbance, luminescence, FRET, mass spectrometry, etc.).
• Rigorous and detail‑oriented approach to data analysis and interpretation.
• Knowledge of protein structure‑function interpretation and proficiency with software to visualize protein structures.
• Strong analytical and problem‑solving skills with the ability to work independently.
• Excellent written and verbal communication skills, including the ability to communicate complex concepts to a variety of audiences.

Preferred Skills

• Experience in target ID and hit ID stage programs in biotech.
• Proficient with software to model multi‑step enzyme reactions (DynaFit, SimBiology, PySB, etc.).
• Familiarity with modern laboratory automation, data systems, and analytics and ability to design experiments to take advantage of these systems.

Base Pay Salary Range

$144,000 — $180,000 USD

Equal Opportunity Employer

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.