Revolution Medicines
Senior Scientist I, Protein Biochemistry/Enzymology
Revolution Medicines, San Francisco, California, United States, 94199
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Senior Scientist I, Protein Biochemistry/Enzymology
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Revolution Medicines Revolution Medicines is a clinical‑stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity
Design, develop, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and enable hit finding and validation efforts. Perform kinetic studies to support a deep understanding of small molecules with complex mechanisms of action, including covalent and non‑covalent molecular glue inhibitors and activators. Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities. Support cross‑functional teams to generate novel insights and drive drug discovery and development. Effectively communicate findings to diverse audiences through presentations, reports, and publications. Required Skills, Experience and Education
Ph.D. in Biochemistry, Enzymology, Chemical Biology, or a related field with 5–8 years of experience, preferably in an industrial setting. Thorough understanding of enzyme kinetics and the ability to design, analyze, and interpret experimental results. Hands‑on experience handling recombinant proteins and analyzing activity through experimental assays (fluorescence, absorbance, luminescence, FRET, mass spectrometry, etc.). Rigorous and detail‑oriented approach to data analysis and interpretation. Knowledge of protein structure‑function interpretation and proficiency with software to visualize protein structures. Strong analytical and problem‑solving skills with the ability to work independently. Excellent written and verbal communication skills, including the ability to communicate complex concepts to a variety of audiences. Preferred Skills
Experience in target ID and hit ID stage programs in biotech. Proficient with software to model multi‑step enzyme reactions (DynaFit, SimBiology, PySB, etc.). Familiarity with modern laboratory automation, data systems, and analytics and ability to design experiments to take advantage of these systems. Base Pay Salary Range
$144,000 — $180,000 USD Equal Opportunity Employer
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
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Senior Scientist I, Protein Biochemistry/Enzymology
role at
Revolution Medicines Revolution Medicines is a clinical‑stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity
Design, develop, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and enable hit finding and validation efforts. Perform kinetic studies to support a deep understanding of small molecules with complex mechanisms of action, including covalent and non‑covalent molecular glue inhibitors and activators. Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities. Support cross‑functional teams to generate novel insights and drive drug discovery and development. Effectively communicate findings to diverse audiences through presentations, reports, and publications. Required Skills, Experience and Education
Ph.D. in Biochemistry, Enzymology, Chemical Biology, or a related field with 5–8 years of experience, preferably in an industrial setting. Thorough understanding of enzyme kinetics and the ability to design, analyze, and interpret experimental results. Hands‑on experience handling recombinant proteins and analyzing activity through experimental assays (fluorescence, absorbance, luminescence, FRET, mass spectrometry, etc.). Rigorous and detail‑oriented approach to data analysis and interpretation. Knowledge of protein structure‑function interpretation and proficiency with software to visualize protein structures. Strong analytical and problem‑solving skills with the ability to work independently. Excellent written and verbal communication skills, including the ability to communicate complex concepts to a variety of audiences. Preferred Skills
Experience in target ID and hit ID stage programs in biotech. Proficient with software to model multi‑step enzyme reactions (DynaFit, SimBiology, PySB, etc.). Familiarity with modern laboratory automation, data systems, and analytics and ability to design experiments to take advantage of these systems. Base Pay Salary Range
$144,000 — $180,000 USD Equal Opportunity Employer
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
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