Phathom Pharmaceuticals
Director Medical Affairs
Phathom Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of gastrointestinal (GI) diseases. With exclusive rights in the United States, Europe, and Canada to vonoprazan—a first‑class potassium‑competitive acid blocker (PCAB)—Phathom is working to transform the treatment of acid‑related disorders.
Current Portfolio
VOQUEZNA® (vonoprazan) tablets, approved for the treatment of heartburn associated with Non‑Erosive GERD as well as the healing and maintenance of healing of Erosive GERD
VOQUEZNA® TRIPLE PAK® (vonoprazan, amoxicillin, clarithromycin) and VOQUEZNA® DUAL PAK® (vonoprazan, amoxicillin), approved for the treatment of H. pylori infection in adults
Beyond our commercialized products, we are advancing a pipeline focused on innovative treatments for other acid‑related GI disorders, including Eosinophilic Esophagitis (EoE).
Culture & Values At Phathom, we are fueled by innovation, driven by purpose, and united by a shared commitment to improving patient outcomes. Our team comprises seasoned GI and industry experts with a proven track record of delivering groundbreaking therapies. We seek motivated, innovative problem‑solvers who excel in fast‑paced, collaborative environments and are eager to make an impact. In August 2025, we proudly earned Great Place to Work® certification, with 91 % of surveyed employees affirming that Phathom is an exceptional workplace.
Responsibilities / Objectives
Provide senior‑level medical and scientific leadership within the Promotional Review Committee (PRC) and Medical Review Committee (MRC), ensuring strategic, scientifically accurate, and compliant promotional and non‑promotional materials.
Oversee the Medical Information strategy and ensure the development of high‑quality, balanced, and scientifically rigorous medical information responses for HCPs and patients.
Serve as a senior therapeutic‑area expert, maintaining deep knowledge of clinical evidence, competitive landscape, treatment guidelines, and unmet needs to inform brand and medical strategy.
Guide cross‑functional teams (Commercial, Legal, Regulatory, R&D) in developing scientifically supportable claims, identifying evidence gaps, and shaping data‑generation needs.
Accountabilities
Lead Medical Affairs representation in PRC/MRC, providing authoritative medical assessment of claims, references, data relevance, and scientific rigor.
Ensure promotional materials reflect accurate, balanced, and supportable scientific content and provide proactive recommendations for compliant claim alternatives.
Oversee Medical Information content development, including standard response letters, escalated inquiries, and cross‑functional alignment of medical messaging.
Partner with Commercial, Regulatory, Legal, and R&D colleagues to support brand strategy, future claim feasibility, and risk‑mitigation planning.
Maintain subject‑matter expertise in disease state, guidelines, and competitive intelligence to inform internal teams and influence medical strategy.
Lead medical information and scientific engagement activities at professional congresses, ensuring appropriate training, staffing, and documentation.
Provide medical training for internal teams (Commercial, MSLs, Medical Affairs) on scientific and promotional standards.
Education & Experience
Advanced scientific degree required (PharmD, PhD, MD preferred).
At least 6 years of Medical Affairs experience, with PRC/MRC involvement preferred. Senior title may be considered based on tenure and experience, including launch strategy or major regulatory milestone support.
Deep expertise in clinical development, therapeutic guidelines, competitor landscape, and scientific data interpretation.
Extensive understanding of FDA promotional regulations, OPDP standards, and medical‑legal compliance.
Excellent written and verbal communication skills with the ability to influence cross‑functional partners.
Strong organizational skills and the ability to manage complex workloads and competing priorities.
Core Values
Perseverance – With hard work and determination, together we overcome all obstacles.
Humble – We put others first, remain grounded, and let our work speak for itself.
Accountable – We are reliable and take personal responsibility in all that we do. We take pride and ownership in our work every day.
Transparent – We say what we mean, debate openly and respectfully, and have no hidden agendas.
Entrepreneurial – We are nimble, agile, and embrace innovation. We challenge the status quo, enjoy change, and approach problems unconventionally.
Working At Phathom – Benefits
Highly competitive medical, dental, and vision coverage options with low monthly premiums.
Roth & Traditional 401(k) savings plan with annual employer match.
Long‑term incentive equity compensation program.
Employee Stock Purchase Plan (ESPP).
Comprehensive paid leave programs, including 16 weeks of paid parental leave for all new parents and a 4‑week part‑time Bridge‑Back‑to‑Work Program.
Hybrid and Flex Working Arrangements.
Unlimited Time Off.
17 paid company holidays in addition to a year‑end winter shutdown period.
Annual Fitness & Wellbeing Reimbursement.
Company‑provided Life and Accidental Death & Dismemberment (AD&D) insurance.
Company‑provided short and long‑term disability benefits.
Company‑funded HSA plan.
Accident and Hospital Indemnity insurance.
Employee Assistance Program (EAP).
Employee recognition program.
Employee discounts.
Compensation Annual Base Salary: $210,000 - $240,000
EEO Statement Phathom is an equal‑opportunity employer that is committed to inclusion and diversity and provides equal opportunity for all applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, Veteran status, or other legally protected characteristics. Applicants with a disability who require a reasonable accommodation for any part of the application, interview or hiring process can contact us by sending an email to careers@phathompharma.com.
Seniority Level Director
Employment Type Full‑time
Job Function Strategy/Planning and Information Technology
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Current Portfolio
VOQUEZNA® (vonoprazan) tablets, approved for the treatment of heartburn associated with Non‑Erosive GERD as well as the healing and maintenance of healing of Erosive GERD
VOQUEZNA® TRIPLE PAK® (vonoprazan, amoxicillin, clarithromycin) and VOQUEZNA® DUAL PAK® (vonoprazan, amoxicillin), approved for the treatment of H. pylori infection in adults
Beyond our commercialized products, we are advancing a pipeline focused on innovative treatments for other acid‑related GI disorders, including Eosinophilic Esophagitis (EoE).
Culture & Values At Phathom, we are fueled by innovation, driven by purpose, and united by a shared commitment to improving patient outcomes. Our team comprises seasoned GI and industry experts with a proven track record of delivering groundbreaking therapies. We seek motivated, innovative problem‑solvers who excel in fast‑paced, collaborative environments and are eager to make an impact. In August 2025, we proudly earned Great Place to Work® certification, with 91 % of surveyed employees affirming that Phathom is an exceptional workplace.
Responsibilities / Objectives
Provide senior‑level medical and scientific leadership within the Promotional Review Committee (PRC) and Medical Review Committee (MRC), ensuring strategic, scientifically accurate, and compliant promotional and non‑promotional materials.
Oversee the Medical Information strategy and ensure the development of high‑quality, balanced, and scientifically rigorous medical information responses for HCPs and patients.
Serve as a senior therapeutic‑area expert, maintaining deep knowledge of clinical evidence, competitive landscape, treatment guidelines, and unmet needs to inform brand and medical strategy.
Guide cross‑functional teams (Commercial, Legal, Regulatory, R&D) in developing scientifically supportable claims, identifying evidence gaps, and shaping data‑generation needs.
Accountabilities
Lead Medical Affairs representation in PRC/MRC, providing authoritative medical assessment of claims, references, data relevance, and scientific rigor.
Ensure promotional materials reflect accurate, balanced, and supportable scientific content and provide proactive recommendations for compliant claim alternatives.
Oversee Medical Information content development, including standard response letters, escalated inquiries, and cross‑functional alignment of medical messaging.
Partner with Commercial, Regulatory, Legal, and R&D colleagues to support brand strategy, future claim feasibility, and risk‑mitigation planning.
Maintain subject‑matter expertise in disease state, guidelines, and competitive intelligence to inform internal teams and influence medical strategy.
Lead medical information and scientific engagement activities at professional congresses, ensuring appropriate training, staffing, and documentation.
Provide medical training for internal teams (Commercial, MSLs, Medical Affairs) on scientific and promotional standards.
Education & Experience
Advanced scientific degree required (PharmD, PhD, MD preferred).
At least 6 years of Medical Affairs experience, with PRC/MRC involvement preferred. Senior title may be considered based on tenure and experience, including launch strategy or major regulatory milestone support.
Deep expertise in clinical development, therapeutic guidelines, competitor landscape, and scientific data interpretation.
Extensive understanding of FDA promotional regulations, OPDP standards, and medical‑legal compliance.
Excellent written and verbal communication skills with the ability to influence cross‑functional partners.
Strong organizational skills and the ability to manage complex workloads and competing priorities.
Core Values
Perseverance – With hard work and determination, together we overcome all obstacles.
Humble – We put others first, remain grounded, and let our work speak for itself.
Accountable – We are reliable and take personal responsibility in all that we do. We take pride and ownership in our work every day.
Transparent – We say what we mean, debate openly and respectfully, and have no hidden agendas.
Entrepreneurial – We are nimble, agile, and embrace innovation. We challenge the status quo, enjoy change, and approach problems unconventionally.
Working At Phathom – Benefits
Highly competitive medical, dental, and vision coverage options with low monthly premiums.
Roth & Traditional 401(k) savings plan with annual employer match.
Long‑term incentive equity compensation program.
Employee Stock Purchase Plan (ESPP).
Comprehensive paid leave programs, including 16 weeks of paid parental leave for all new parents and a 4‑week part‑time Bridge‑Back‑to‑Work Program.
Hybrid and Flex Working Arrangements.
Unlimited Time Off.
17 paid company holidays in addition to a year‑end winter shutdown period.
Annual Fitness & Wellbeing Reimbursement.
Company‑provided Life and Accidental Death & Dismemberment (AD&D) insurance.
Company‑provided short and long‑term disability benefits.
Company‑funded HSA plan.
Accident and Hospital Indemnity insurance.
Employee Assistance Program (EAP).
Employee recognition program.
Employee discounts.
Compensation Annual Base Salary: $210,000 - $240,000
EEO Statement Phathom is an equal‑opportunity employer that is committed to inclusion and diversity and provides equal opportunity for all applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, Veteran status, or other legally protected characteristics. Applicants with a disability who require a reasonable accommodation for any part of the application, interview or hiring process can contact us by sending an email to careers@phathompharma.com.
Seniority Level Director
Employment Type Full‑time
Job Function Strategy/Planning and Information Technology
#J-18808-Ljbffr