Dana-Farber Cancer Institute
Antibody Discovery & Engineering Scientist I/II – CAR-T Cell & Antibody Therapie
Dana-Farber Cancer Institute, Boston, Massachusetts, us, 02298
Antibody Discovery & Engineering Scientist I/II – CAR‑T Cell & Antibody Therapies
Join to apply for the
Antibody Discovery & Engineering Scientist I/II – CAR‑T Cell & Antibody Therapies
role at
Dana‑Farber Cancer Institute .
1 week ago – be among the first 25 applicants.
Dana‑Farber Cancer Institute is seeking an experienced PhD‑level scientist to join the antibody discovery and antibody‑based therapeutics development‑focused LAUNCHPAD or the Lab for Antibody and Nanobody Phage Display and Discovery. A pre‑clinical strategic center, LAUNCHPAD’s mission is to streamline “discovery to translation” of antibody‑based immunotherapies for cancer. The LAUNCHPAD team works closely with academic partners to design experimental strategies to identify promising antibody ‘hits’ and to engineer hits that generate potential therapeutic bispecific and CAR T‑cell immunotherapies. The candidate should be exceptionally motivated with a passion for multidisciplinary teamwork to design, screen, and engineer immunotherapy candidates and advance next‑generation therapies.
The Dana‑Farber Cancer Institute brings together world‑renowned clinicians, innovative researchers, and dedicated professionals, allied under a common mission of conquering cancer. With talented people and best technologies, we provide compassionate and comprehensive care, conduct research that advances treatment, educate tomorrow’s physicians/researchers, reach underserved community members, and collaborate with partners, including other Harvard Medical School‑affiliated hospitals.
This “leading from the bench” role provides scientific and technical expertise within multidisciplinary project teams focused on the development of antibody‑based immunotherapies.
Develop antibody selection strategies to identify novel, fully human binders from a custom library using phage and yeast display.
Design experiments to characterize binding, function, biophysical properties, and developability of antibody‑based binders used to generate antibody‑based drug modalities including CARs, multispecific T cell engagers, etc.
Design, produce, and optimize the expression and in‑vitro function of logic‑gated and/or multispecific CARs and antibodies.
Evaluate novel approaches to antibody and CAR‑T screening, including construction of candidate libraries and high‑throughput pooled or arrayed screening approaches leveraging automation.
Design and execute workflows for producing and functionally screening antibody‑based biologics and CAR‑T candidates to identify leads for clinical translation.
Collaborate with team members across groups and mentor junior lab members to implement best practices for the operation and maintenance of immunotherapy production, screening, and engineering platforms.
Co‑author technical reports and manuscripts for publication or presentation at internal and external meetings.
Operate and maintain laboratory instruments.
PhD scientist with experience in antibody screening, engineering, and/or CAR‑T engineering. A candidate with an M.S. degree and substantial experience (>7 years) may also be considered. Industry research experience is a plus.
Strong track record, hands‑on experience, and in‑depth knowledge in at least two of the following domain areas:
Antibody discovery (phage and yeast display strategies, affinity maturation approaches, etc.).
Antibody expression and characterization technologies including but not limited to purity and mispairing (SEC), aggregation/stability (DLS), and affinity characterization (SPR).
Generative AI tools for protein or antibody design (exposure and familiarity to AlphaFold3, RoseTTAFold, ProteinMPNN, MOE, and/or other bioinformatics tools for protein modeling and de novo design).
Previous hands‑on experience engineering antibody and/or CAR‑T candidates and executing key functional assays for candidate screening (assessments of cytotoxicity via plate‑based or imaging‑based assays, tonic signaling, developability, etc.).
Exceptionally self‑motivated and capable of taking scientific initiatives.
Excellent communication (written and verbal) and troubleshooting skills as well as the ability to work with a wide variety of collaborators.
Outstanding planning, organizational, and multi‑tasking skills.
Must consider attention to detail a strength.
Ability to work within a fast‑paced team environment.
Only applicants that submit a cover letter and a detailed CV will be considered. Following a pre‑screen interview, the candidate will be requested to provide the contact information for three references.
Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and the candidate’s relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).
$80,000 – $83,000 –
SCIENTIST I At Dana‑Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. We are equally committed to diversifying our faculty and staff. Cancer knows no boundaries, and when it comes to hiring the most dedicated and diverse professionals, neither do we.
Dana‑Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Seniority level Mid‑Senior level
Employment type Full‑time
Job function Other
Industries Hospitals and Health Care
Referrals increase your chances of interviewing at Dana‑Farber Cancer Institute by 2x.
Boston, MA $110,000.00–$140,000.00 3 days ago
Waltham, MA $58,000.00–$65,000.00 1 month ago
Cambridge, MA $80,000.00–$135,000.00 2 weeks ago
#J-18808-Ljbffr
Antibody Discovery & Engineering Scientist I/II – CAR‑T Cell & Antibody Therapies
role at
Dana‑Farber Cancer Institute .
1 week ago – be among the first 25 applicants.
Dana‑Farber Cancer Institute is seeking an experienced PhD‑level scientist to join the antibody discovery and antibody‑based therapeutics development‑focused LAUNCHPAD or the Lab for Antibody and Nanobody Phage Display and Discovery. A pre‑clinical strategic center, LAUNCHPAD’s mission is to streamline “discovery to translation” of antibody‑based immunotherapies for cancer. The LAUNCHPAD team works closely with academic partners to design experimental strategies to identify promising antibody ‘hits’ and to engineer hits that generate potential therapeutic bispecific and CAR T‑cell immunotherapies. The candidate should be exceptionally motivated with a passion for multidisciplinary teamwork to design, screen, and engineer immunotherapy candidates and advance next‑generation therapies.
The Dana‑Farber Cancer Institute brings together world‑renowned clinicians, innovative researchers, and dedicated professionals, allied under a common mission of conquering cancer. With talented people and best technologies, we provide compassionate and comprehensive care, conduct research that advances treatment, educate tomorrow’s physicians/researchers, reach underserved community members, and collaborate with partners, including other Harvard Medical School‑affiliated hospitals.
This “leading from the bench” role provides scientific and technical expertise within multidisciplinary project teams focused on the development of antibody‑based immunotherapies.
Develop antibody selection strategies to identify novel, fully human binders from a custom library using phage and yeast display.
Design experiments to characterize binding, function, biophysical properties, and developability of antibody‑based binders used to generate antibody‑based drug modalities including CARs, multispecific T cell engagers, etc.
Design, produce, and optimize the expression and in‑vitro function of logic‑gated and/or multispecific CARs and antibodies.
Evaluate novel approaches to antibody and CAR‑T screening, including construction of candidate libraries and high‑throughput pooled or arrayed screening approaches leveraging automation.
Design and execute workflows for producing and functionally screening antibody‑based biologics and CAR‑T candidates to identify leads for clinical translation.
Collaborate with team members across groups and mentor junior lab members to implement best practices for the operation and maintenance of immunotherapy production, screening, and engineering platforms.
Co‑author technical reports and manuscripts for publication or presentation at internal and external meetings.
Operate and maintain laboratory instruments.
PhD scientist with experience in antibody screening, engineering, and/or CAR‑T engineering. A candidate with an M.S. degree and substantial experience (>7 years) may also be considered. Industry research experience is a plus.
Strong track record, hands‑on experience, and in‑depth knowledge in at least two of the following domain areas:
Antibody discovery (phage and yeast display strategies, affinity maturation approaches, etc.).
Antibody expression and characterization technologies including but not limited to purity and mispairing (SEC), aggregation/stability (DLS), and affinity characterization (SPR).
Generative AI tools for protein or antibody design (exposure and familiarity to AlphaFold3, RoseTTAFold, ProteinMPNN, MOE, and/or other bioinformatics tools for protein modeling and de novo design).
Previous hands‑on experience engineering antibody and/or CAR‑T candidates and executing key functional assays for candidate screening (assessments of cytotoxicity via plate‑based or imaging‑based assays, tonic signaling, developability, etc.).
Exceptionally self‑motivated and capable of taking scientific initiatives.
Excellent communication (written and verbal) and troubleshooting skills as well as the ability to work with a wide variety of collaborators.
Outstanding planning, organizational, and multi‑tasking skills.
Must consider attention to detail a strength.
Ability to work within a fast‑paced team environment.
Only applicants that submit a cover letter and a detailed CV will be considered. Following a pre‑screen interview, the candidate will be requested to provide the contact information for three references.
Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and the candidate’s relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).
$80,000 – $83,000 –
SCIENTIST I At Dana‑Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. We are equally committed to diversifying our faculty and staff. Cancer knows no boundaries, and when it comes to hiring the most dedicated and diverse professionals, neither do we.
Dana‑Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Seniority level Mid‑Senior level
Employment type Full‑time
Job function Other
Industries Hospitals and Health Care
Referrals increase your chances of interviewing at Dana‑Farber Cancer Institute by 2x.
Boston, MA $110,000.00–$140,000.00 3 days ago
Waltham, MA $58,000.00–$65,000.00 1 month ago
Cambridge, MA $80,000.00–$135,000.00 2 weeks ago
#J-18808-Ljbffr