Draig Therapeutics
Director, Development DMPK
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Director, Development DMPK
role at
Draig Therapeutics .
About Draig Therapeutics: Draig Therapeutics is an exciting, rapidly growing clinical‑stage biotech backed by a transformative $140 million Series A financing — one of the largest ever in neuropsychiatric drug development. We are pioneering innovative small‑molecule therapies aimed at fundamentally transforming the treatment landscape for depression and neurological disorders.
Why Join Draig? At Draig Therapeutics, you’ll join a science‑first, mission‑driven biotech that redefines what a small, agile, and deeply collaborative organization can achieve. Backed by strong investors and propelled by a bold CNS discovery pipeline, Draig brings together world‑class scientists, a caring culture, and the energy of a company on an incredible growth trajectory. Your voice matters, your expertise has real impact, and your work directly influences how promising molecules move from concept into the clinic.
Responsibilities The position is a senior, hands‑on scientific and operational leadership role focused on defining and implementing Draig’s DMPK strategy, managing outsourced studies, and integrating translational PK/PD understanding into development decisions.
Strategic and Scientific Leadership
Define and deliver DMPK strategy across all programmes, ensuring alignment with nonclinical, clinical, and regulatory development plans.
Provide scientific leadership in the design, conduct, and interpretation of nonclinical and clinical ADME/PK, bioanalysis, metabolite profiling, drug‑drug interaction, and PK/PD modelling and simulation studies.
Apply world‑class science to drive a translational understanding of drug disposition and PK/PD, supporting decision‑making from candidate selection through clinical proof‑of‑concept.
Champion model‑informed drug development (MIDD) and ensure application of modern ADME and PK modelling principles to guide dose selection and de‑risk development.
Drive best‑practice sharing across internal and external teams to ensure scientific excellence and consistency.
Operational Oversight and Delivery
Manage multiple CROs and specialist consultants conducting in‑vitro and in‑vivo ADME/PK, bioanalytical, and TK studies.
Oversee study design, execution, data quality, and reporting, ensuring compliance with global regulatory standards (FDA, EMA, MHRA, ICH).
Efficiently manage outsourcing budgets, timelines, and capacity to deliver high‑quality data packages across several parallel projects.
Proactively identify study issues, coordinate resolution with CROs, and ensure delivery of accurate, submission‑ready reports.
Maintain oversight of bioanalytical strategies and ensure appropriate validation and GLP compliance where required.
Integration and Cross‑Functional Collaboration
Partner with Nonclinical Safety to interpret exposure and metabolism data, supporting toxicological and safety de‑risking strategies.
Collabosr closely with Clinical Development, CMC, and Regulatory Affairs to integrate DMPK insights into clinical protocols, dose selection, and development strategy.
Provide high‑quality DMPK input into protocols, Investigator’s Brochures, regulatory submissions (INDs, CTAs), and responses to agency queries.
Represent DMPK within internal governance forums and at meetings with external stakeholders and regulators, as required.
Scientific Influence and Organisational Growth
Keep abreast of advances in ADME science, modelling tools, and regulatory guidance, applying these to improve Draig’s approaches.
Engage with the wider DMPK scientific community and key opinion leaders to stay current on emerging methodologies.
Contribute to developing internal DMPK capability through mentoring, training, and establishing best practices as Draig’s pipeline and team expand.
Provide clear, concise communication of DMPK findings and their implications to senior leadership and multidisciplinary teams.
Education and Experience
PhD (or equivalent) in Pharmacology, Biochemistry, Pharmaceutical Sciences, or a related discipline.
10+ years’ established experience in DMPK/ADME within biotech or pharmaceutical drug development, spanning discovery through early clinical phases.
Strong expertise in bioanalysis, PK/PD modelling, and interpretation of both nonclinical and clinical ADME data.
Proven ability to design and oversee complex outsourced DMPK programmes, including vendor management, budget oversight, and quality control.
Deep understanding of PK, PK/PD, ADME, metabolism, drug‑drug interactions, and modelling approaches to support drug development decisions.
Demonstrated success contributing to regulatory submissions and supporting health authority interactions.
Skilled in proactive issue identification, troubleshooting, and resolution under evolving priorities.
Excellent verbal, written, and interpersonal communication skills, with the ability to influence and collaborate across multidisciplinary teams.
Preferred Skills
Experience in CNS drug development and blood‑brain barrier penetration considerations.
Proficiency in PK/PD modelling and simulation platforms (e.g., Phoenix, GastroPlus, Simcyp).
Experience with clinical pharmacokinetics and clinical ADME data across early and mid‑stage trials.
Experience building or scaling DMPK capabilities within a fast‑growing biotech organisation.
Location Metro Boston, USA; London, UK; and Cardiff, UK.
Draig Therapeutics, Inc. is an equal employment opportunity employer. It does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.
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Director, Development DMPK
role at
Draig Therapeutics .
About Draig Therapeutics: Draig Therapeutics is an exciting, rapidly growing clinical‑stage biotech backed by a transformative $140 million Series A financing — one of the largest ever in neuropsychiatric drug development. We are pioneering innovative small‑molecule therapies aimed at fundamentally transforming the treatment landscape for depression and neurological disorders.
Why Join Draig? At Draig Therapeutics, you’ll join a science‑first, mission‑driven biotech that redefines what a small, agile, and deeply collaborative organization can achieve. Backed by strong investors and propelled by a bold CNS discovery pipeline, Draig brings together world‑class scientists, a caring culture, and the energy of a company on an incredible growth trajectory. Your voice matters, your expertise has real impact, and your work directly influences how promising molecules move from concept into the clinic.
Responsibilities The position is a senior, hands‑on scientific and operational leadership role focused on defining and implementing Draig’s DMPK strategy, managing outsourced studies, and integrating translational PK/PD understanding into development decisions.
Strategic and Scientific Leadership
Define and deliver DMPK strategy across all programmes, ensuring alignment with nonclinical, clinical, and regulatory development plans.
Provide scientific leadership in the design, conduct, and interpretation of nonclinical and clinical ADME/PK, bioanalysis, metabolite profiling, drug‑drug interaction, and PK/PD modelling and simulation studies.
Apply world‑class science to drive a translational understanding of drug disposition and PK/PD, supporting decision‑making from candidate selection through clinical proof‑of‑concept.
Champion model‑informed drug development (MIDD) and ensure application of modern ADME and PK modelling principles to guide dose selection and de‑risk development.
Drive best‑practice sharing across internal and external teams to ensure scientific excellence and consistency.
Operational Oversight and Delivery
Manage multiple CROs and specialist consultants conducting in‑vitro and in‑vivo ADME/PK, bioanalytical, and TK studies.
Oversee study design, execution, data quality, and reporting, ensuring compliance with global regulatory standards (FDA, EMA, MHRA, ICH).
Efficiently manage outsourcing budgets, timelines, and capacity to deliver high‑quality data packages across several parallel projects.
Proactively identify study issues, coordinate resolution with CROs, and ensure delivery of accurate, submission‑ready reports.
Maintain oversight of bioanalytical strategies and ensure appropriate validation and GLP compliance where required.
Integration and Cross‑Functional Collaboration
Partner with Nonclinical Safety to interpret exposure and metabolism data, supporting toxicological and safety de‑risking strategies.
Collabosr closely with Clinical Development, CMC, and Regulatory Affairs to integrate DMPK insights into clinical protocols, dose selection, and development strategy.
Provide high‑quality DMPK input into protocols, Investigator’s Brochures, regulatory submissions (INDs, CTAs), and responses to agency queries.
Represent DMPK within internal governance forums and at meetings with external stakeholders and regulators, as required.
Scientific Influence and Organisational Growth
Keep abreast of advances in ADME science, modelling tools, and regulatory guidance, applying these to improve Draig’s approaches.
Engage with the wider DMPK scientific community and key opinion leaders to stay current on emerging methodologies.
Contribute to developing internal DMPK capability through mentoring, training, and establishing best practices as Draig’s pipeline and team expand.
Provide clear, concise communication of DMPK findings and their implications to senior leadership and multidisciplinary teams.
Education and Experience
PhD (or equivalent) in Pharmacology, Biochemistry, Pharmaceutical Sciences, or a related discipline.
10+ years’ established experience in DMPK/ADME within biotech or pharmaceutical drug development, spanning discovery through early clinical phases.
Strong expertise in bioanalysis, PK/PD modelling, and interpretation of both nonclinical and clinical ADME data.
Proven ability to design and oversee complex outsourced DMPK programmes, including vendor management, budget oversight, and quality control.
Deep understanding of PK, PK/PD, ADME, metabolism, drug‑drug interactions, and modelling approaches to support drug development decisions.
Demonstrated success contributing to regulatory submissions and supporting health authority interactions.
Skilled in proactive issue identification, troubleshooting, and resolution under evolving priorities.
Excellent verbal, written, and interpersonal communication skills, with the ability to influence and collaborate across multidisciplinary teams.
Preferred Skills
Experience in CNS drug development and blood‑brain barrier penetration considerations.
Proficiency in PK/PD modelling and simulation platforms (e.g., Phoenix, GastroPlus, Simcyp).
Experience with clinical pharmacokinetics and clinical ADME data across early and mid‑stage trials.
Experience building or scaling DMPK capabilities within a fast‑growing biotech organisation.
Location Metro Boston, USA; London, UK; and Cardiff, UK.
Draig Therapeutics, Inc. is an equal employment opportunity employer. It does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.
#J-18808-Ljbffr