Associate Principal Scientist, Research Science

* Design and initiate target-focused antibody discovery strategies* Design, develop and optimize selection methods to enrich for affinity, specificity, cross‑reactivity, and epitope diversity* Interface with CROs or platform vendors for immunization or display campaigns as needed* Conduct affinity maturation, speciation (e.g. caninization/felinization), and specificity engineering (e.g., CDR grafting, back‑mutation, structure‑guided design)* Engineer formats including Fabs, scFvs, VHHs, bispecifics, multispecifics, and Fc variants for tailored effector functions and half‑life* Apply in silico tools for sequence liability assessment, developability predictions, and structure modeling* Work with other team members to characterize biophysical and biochemical properties* Assess binding by ELISA, SPR/BLI, flow cytometry* Perform epitope binning/mapping and cross‑species reactivity* Collaborate with biology teams to evaluate potency, MOA, and functional readouts* Work with CMC teams to screen for developability (solubility, stability, aggregation, viscosity, PTM liabilities) and implement sequence fixes* Provide input on sequence selection and manufacturability risks* Plan, prioritize, and execute experiments; analyze data and present in cross‑functional forums* Author study reports and contribute to patent filings and regulatory documents* Mentor junior associates and help implement best practices and data management* Apply knowledge of key signal transduction pathways to design appropriate assay systems for characterization of biological and pharmacological effects of new veterinary therapeutics.* Develop and manage project specific milestones and timelines.* Manage the R&D relationships with external service providers.* Prepare progress reports and make presentations to stakeholders.* Stay informed of external advances & technologies to enhance the product development portfolio.* Communicate progress and plans to a variety of stakeholders with diverse expertise.* Provide support, coaching or assistance to other team members.* 3+ years relevant work experience in antibody discovery/engineering* Demonstrated experience with at least one display platform (phage, yeast, or mammalian) or immunization‑based antibody discovery* Hands‑on expertise in antibody engineering (speciation, affinity maturation, specificity tuning, format engineering)* Proficiency in biomolecular interaction methods and analytical characterization (e.g., SPR/BLI)* Proficiency with developability assessment and mitigation of sequence liabilities (e.g., deamidation, isomerization, oxidation, glycosylation hotspots)* Strong data analysis and documentation skills* Proficiency with molecular biology and sequence design tools (e.g., Geneious, MOE/Rosetta, IgBLAST/IMGT)* Ability to interpret and analyze data from key biological, biochemical and immunological assay systems and design appropriate follow-on experiments* Ability to contribute or manage more than one project at a time.* Excellent communication and cross‑functional collaboration skills* Experience with bispecific/multispecific formats* Experience with Fc engineering for effector function and half‑life* Experience with computational antibody design* Familiarity with early CMC and developability workflows* Experience managing CROs or external partners**Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance #J-18808-Ljbffr