Nesco Resource
Position Summary
We are seeking a highly motivated Senior System Engineer to join our End-to-End Solution Integration Chapter supporting Next-Generation Diagnostic Solutions. In this hands‑on role, you will drive feasibility, development, and integration of complex multi‑disciplinary systems spanning sample preparation, library preparation, molecular detection technologies (e.g., digital PCR, sequencing by synthesis, microarray), and bioinformatics/data processing pipelines. You will collaborate with assay, software, hardware, and bioinformatics teams to define, integrate, and optimize system‑level performance, ensuring technical robustness and operational scalability across diverse technologies. This role is ideal for a systems‑minded engineer with direct industry experience in sequencing workflows, strong analytical and statistical skills, and the ability to influence cross‑functional projects without formal people‑management responsibilities.
Key Responsibilities
Drive system‑level development activities across wet lab workflows, instruments, and data pipelines for next generation diagnostic solutions.
Perform hands‑on system integration and troubleshooting of workflows including sample extraction, library preparation, molecular detections, and data transfer.
Partner with assay, software and bioinformatics teams to ensure seamless integration of sequencing output with downstream analysis pipelines.
Contribute to system architecture, requirements definition.
Apply statistical analysis and Design of Experiments (DoE) methodologies (e.g., JMP, ANOVA, regression) to characterize, optimize, and set subsystem specifications.
Verification, Validation & On Market support
Plan, design and execute verification and validation (V&V) test cases to ensure comprehensive coverage of requirements.
Analyze test results for accuracy, validity, and relevance to user needs.
Support post‑launch troubleshooting and field investigations through failure mode and root cause analyses.
Collaboration & Influence
Represent Systems Engineering in cross‑functional project teams on key topics such as requirements management, defect management, system integration, etc.
Collaborate closely with assay scientists, software developers, hardware engineers, and bioinformaticians to align on end‑to‑end workflows.
Contribute to system documentation, including requirements, specifications, integration plans, and verification results.
Identify and lead opportunities for workflow simplification, automation, and continuous improvement.
Qualifications We are hiring a Senior System Engineer with major in Systems Engineering, Bioengineering, Biomedical Engineering. The final compensation will be determined by the candidate's experience and qualifications.
Senior Engineer Level:
PhD degree with related field with 5 years of relevant industry experience is highly valued.
Master's degree with 10 years of relevant industry experience.
Bachelor's degree with 10 years of relevant industry experience.
Experience
Hands‑on industrial experience with sequencing related workflows, including nucleic acid extraction, library preparation, and sequencing.
Proven lab troubleshooting experience in sequencing workflows and PCR-based workflows.
Exposure to bioinformatics/data processing pipelines for sequencing output (variant calling, data QC) is highly desirable.
Experience with statistical tools and DoE methodologies (JMP, regression, ANOVA) is required.
Familiarity with system‑level product development in life sciences instrumentation is a plus.
Experience across multiple product life‑cycle stages is a plus.
Experience in digital PCR platforms is desirable.
Experience with developing In‑vitro Diagnostic products is desirable.
Experience in implementing workflow on semiconductor based sensing devices or microfluidic devices is desirable.
Skills
Strong analytical and problem‑solving skills with the ability to work independently.
Excellent written and verbal communication skills to influence cross‑functional stakeholders.
Scripting/programming experience (Python, R, or equivalent) is a plus.
Who You Are You are a fast learner who thrives at the interface of biology, technology, and data. You want to translate complex scientific workflows into reliable, scalable system solutions. You are collaborative, curious, and driven to make an impact across diverse disciplines, and are comfortable operating as an individual contributor with broad cross‑functional influence.
ONSITE POSTION 1 5 days a week
Interview: 1 phone screening 2. Onsite
May do an occasional travel to the Santa Clara jobsite for training etc.
Nesco Resource offers a comprehensive benefits package for our associates, which includes a MEC (Minimum Essential Coverage) plan that encompasses Medical, Vision, Dental, 401K, and EAP (Employee Assistance Program) services.
Nesco Resource provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.
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Key Responsibilities
Drive system‑level development activities across wet lab workflows, instruments, and data pipelines for next generation diagnostic solutions.
Perform hands‑on system integration and troubleshooting of workflows including sample extraction, library preparation, molecular detections, and data transfer.
Partner with assay, software and bioinformatics teams to ensure seamless integration of sequencing output with downstream analysis pipelines.
Contribute to system architecture, requirements definition.
Apply statistical analysis and Design of Experiments (DoE) methodologies (e.g., JMP, ANOVA, regression) to characterize, optimize, and set subsystem specifications.
Verification, Validation & On Market support
Plan, design and execute verification and validation (V&V) test cases to ensure comprehensive coverage of requirements.
Analyze test results for accuracy, validity, and relevance to user needs.
Support post‑launch troubleshooting and field investigations through failure mode and root cause analyses.
Collaboration & Influence
Represent Systems Engineering in cross‑functional project teams on key topics such as requirements management, defect management, system integration, etc.
Collaborate closely with assay scientists, software developers, hardware engineers, and bioinformaticians to align on end‑to‑end workflows.
Contribute to system documentation, including requirements, specifications, integration plans, and verification results.
Identify and lead opportunities for workflow simplification, automation, and continuous improvement.
Qualifications We are hiring a Senior System Engineer with major in Systems Engineering, Bioengineering, Biomedical Engineering. The final compensation will be determined by the candidate's experience and qualifications.
Senior Engineer Level:
PhD degree with related field with 5 years of relevant industry experience is highly valued.
Master's degree with 10 years of relevant industry experience.
Bachelor's degree with 10 years of relevant industry experience.
Experience
Hands‑on industrial experience with sequencing related workflows, including nucleic acid extraction, library preparation, and sequencing.
Proven lab troubleshooting experience in sequencing workflows and PCR-based workflows.
Exposure to bioinformatics/data processing pipelines for sequencing output (variant calling, data QC) is highly desirable.
Experience with statistical tools and DoE methodologies (JMP, regression, ANOVA) is required.
Familiarity with system‑level product development in life sciences instrumentation is a plus.
Experience across multiple product life‑cycle stages is a plus.
Experience in digital PCR platforms is desirable.
Experience with developing In‑vitro Diagnostic products is desirable.
Experience in implementing workflow on semiconductor based sensing devices or microfluidic devices is desirable.
Skills
Strong analytical and problem‑solving skills with the ability to work independently.
Excellent written and verbal communication skills to influence cross‑functional stakeholders.
Scripting/programming experience (Python, R, or equivalent) is a plus.
Who You Are You are a fast learner who thrives at the interface of biology, technology, and data. You want to translate complex scientific workflows into reliable, scalable system solutions. You are collaborative, curious, and driven to make an impact across diverse disciplines, and are comfortable operating as an individual contributor with broad cross‑functional influence.
ONSITE POSTION 1 5 days a week
Interview: 1 phone screening 2. Onsite
May do an occasional travel to the Santa Clara jobsite for training etc.
Nesco Resource offers a comprehensive benefits package for our associates, which includes a MEC (Minimum Essential Coverage) plan that encompasses Medical, Vision, Dental, 401K, and EAP (Employee Assistance Program) services.
Nesco Resource provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.
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