Bristol Myers Squibb
Scientist Protein Engineering Display Technologies
Bristol Myers Squibb, Redwood City, California, United States, 94061
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Scientist Protein Engineering Display Technologies
role at
Bristol Myers Squibb
Overview We are seeking an enthusiastic, creative, and versatile Scientist to join our collaborative Protein Engineering team in Redwood City/Brisbane (CA) to discover and engineer innovative biotherapeutic candidates and drive technological innovation. Our group acts on new ideas in the laboratory and thrives on the design-build-test cycle. You will solve complex protein engineering problems, develop new skills, and use them to implement robust platforms for protein therapeutic optimization. You will collaborate with talented colleagues across biotherapeutics and multiple therapeutic areas, and further support AI/ML workflows. You will present at internal and external meetings, contribute to therapeutic pipeline projects, publications, and patents. Responsibilities include library creation, selection-based assays using protein display library technologies, binder engineering for antibody-target interactions, cross-function and cross-site collaboration.
Responsibilities
Drive efforts to engineer antibodies, multispecifics, and alternative biologics formats for optimal therapeutic performance
Selections on yeast display libraries, routine operation and maintenance of a sorter and analyzer
Library design, library construction, NGS
Collaborate with AI/ML scientists for sequence and library design and support design-build-test cycles
Independently perform routine molecular biology techniques, DNA assembly and cloning, design expression constructs for external synthesis, and coordinate construct and library orders with CROs
Analyze library NGS data using no-code or low-code bioinformatics platforms
Independently perform complex experiments, troubleshoot, expertly analyze and interpret experimental results with strong attention to detail and documentation practices
Present results internally and externally, attend industry conferences
Accomplish goals under project team timelines
Basic Qualifications
Bachelor's Degree with 5+ years of academic or industry experience
Master's Degree with 3+ years of academic or industry experience
PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 0-2 years of academic or industry experience
Preferred Qualifications
PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 0-2 years of relevant post-graduate or biotech/biopharma industry experience
Experience with molecular and microbiology techniques underlying yeast display work
Demonstrated experience in yeast display, antibody/protein library construction, sorting, analytical binding, etc.
Experience in antibody or protein engineering, including, but not limited to, affinity maturation, deep mutational scanning, species cross-reactivity, liability correction, biophysical/physiochemical property remediation, etc.
Flow cytometry and FACS experience is required
Experience in biotherapeutic lead discovery and optimization is desirable
Demonstrated experience in working in a cross-functional organization
Fundamental understanding of proteins, antibodies, and structure-function relationships required. Familiarity with protein structure analysis (Pymol, Chimera, MOE).
DNA and RNA purification, cloning, PCR, Sanger sequencing, NGS library preparation
Familiarity with protein-protein interaction techniques and kinetics (BLI, SPR, on-cell binding)
Bioinformatics or data science experience is desirable (bash, Python, or R)
Proficiency with Microsoft Office suite, FlowJo, Prism, DNA cloning software
Excellent written and oral communication skills
Compensation and Benefits The starting compensation for this job is a range from $122,830 - $148,800, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Careers Site. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following Medical, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
On-site and Equal Opportunity BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role. Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Locations and Opportunities If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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Scientist Protein Engineering Display Technologies
role at
Bristol Myers Squibb
Overview We are seeking an enthusiastic, creative, and versatile Scientist to join our collaborative Protein Engineering team in Redwood City/Brisbane (CA) to discover and engineer innovative biotherapeutic candidates and drive technological innovation. Our group acts on new ideas in the laboratory and thrives on the design-build-test cycle. You will solve complex protein engineering problems, develop new skills, and use them to implement robust platforms for protein therapeutic optimization. You will collaborate with talented colleagues across biotherapeutics and multiple therapeutic areas, and further support AI/ML workflows. You will present at internal and external meetings, contribute to therapeutic pipeline projects, publications, and patents. Responsibilities include library creation, selection-based assays using protein display library technologies, binder engineering for antibody-target interactions, cross-function and cross-site collaboration.
Responsibilities
Drive efforts to engineer antibodies, multispecifics, and alternative biologics formats for optimal therapeutic performance
Selections on yeast display libraries, routine operation and maintenance of a sorter and analyzer
Library design, library construction, NGS
Collaborate with AI/ML scientists for sequence and library design and support design-build-test cycles
Independently perform routine molecular biology techniques, DNA assembly and cloning, design expression constructs for external synthesis, and coordinate construct and library orders with CROs
Analyze library NGS data using no-code or low-code bioinformatics platforms
Independently perform complex experiments, troubleshoot, expertly analyze and interpret experimental results with strong attention to detail and documentation practices
Present results internally and externally, attend industry conferences
Accomplish goals under project team timelines
Basic Qualifications
Bachelor's Degree with 5+ years of academic or industry experience
Master's Degree with 3+ years of academic or industry experience
PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 0-2 years of academic or industry experience
Preferred Qualifications
PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 0-2 years of relevant post-graduate or biotech/biopharma industry experience
Experience with molecular and microbiology techniques underlying yeast display work
Demonstrated experience in yeast display, antibody/protein library construction, sorting, analytical binding, etc.
Experience in antibody or protein engineering, including, but not limited to, affinity maturation, deep mutational scanning, species cross-reactivity, liability correction, biophysical/physiochemical property remediation, etc.
Flow cytometry and FACS experience is required
Experience in biotherapeutic lead discovery and optimization is desirable
Demonstrated experience in working in a cross-functional organization
Fundamental understanding of proteins, antibodies, and structure-function relationships required. Familiarity with protein structure analysis (Pymol, Chimera, MOE).
DNA and RNA purification, cloning, PCR, Sanger sequencing, NGS library preparation
Familiarity with protein-protein interaction techniques and kinetics (BLI, SPR, on-cell binding)
Bioinformatics or data science experience is desirable (bash, Python, or R)
Proficiency with Microsoft Office suite, FlowJo, Prism, DNA cloning software
Excellent written and oral communication skills
Compensation and Benefits The starting compensation for this job is a range from $122,830 - $148,800, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Careers Site. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following Medical, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
On-site and Equal Opportunity BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role. Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Locations and Opportunities If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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