Rangam
RCI-JNJN-70399 Oligonucleotide Analytics Scientist - La Jolla, CA
Rangam, San Diego, California, United States, 92189
Base pay range
$45.00/hr - $51.00/hr Responsibilities
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects 20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis 10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS. 20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. 5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in-class analytical chemistry methodologies such as different column matrices for optimal siRNA characterization Support integrity confirmation requests (such as concentration) by assay development and biology teams 3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA 5% Ensure the supply of laboratory consumables and reagents are in stock as needed Maintain a high level of productivity in the laboratory setting. 2% Present data and reports on project status at individual, group, and departmental meetings. Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Top Three Skills
Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughput analytical capabilities Seniority level
Mid-Senior level Employment type
Contract Job function
Science and Research Industries
Pharmaceutical Manufacturing Biotechnology Research Medical Equipment Manufacturing Location references: La Jolla Shores, CA; Oceanside, CA; Carlsbad, CA
#J-18808-Ljbffr
$45.00/hr - $51.00/hr Responsibilities
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects 20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis 10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS. 20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. 5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in-class analytical chemistry methodologies such as different column matrices for optimal siRNA characterization Support integrity confirmation requests (such as concentration) by assay development and biology teams 3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA 5% Ensure the supply of laboratory consumables and reagents are in stock as needed Maintain a high level of productivity in the laboratory setting. 2% Present data and reports on project status at individual, group, and departmental meetings. Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Top Three Skills
Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughput analytical capabilities Seniority level
Mid-Senior level Employment type
Contract Job function
Science and Research Industries
Pharmaceutical Manufacturing Biotechnology Research Medical Equipment Manufacturing Location references: La Jolla Shores, CA; Oceanside, CA; Carlsbad, CA
#J-18808-Ljbffr