Syracuse University Lubin House
Scientist I, Nucleic Acids Biochemistry
Syracuse University Lubin House, Cambridge, Massachusetts, us, 02140
Overview
Scientist I, Nucleic Acids Biochemistry (contractor) role at Syracuse University Lubin House.
This position focuses on designing and testing nucleic acid payloads for packaging within Anellovector VLPs as part of the Nucleic Acids Biochemistry team.
Position Summary Ring Therapeutics is seeking a Scientist I (contractor) to join the Nucleic Acids Biochemistry team within Platform to help design and test novel nucleic acid payloads for packaging within Anellovector VLPs. The ideal candidate will bring creativity to ideation, gap analysis, design and experimentation revolving around molecular biology and cell culture. We are searching for enthusiastic and highly motivated individuals who are comfortable multitasking and working both within a team and independently on various aspects of nucleic acids payloads within the context of viral vector packaging.
Key Responsibilities
End to end ideate, design and experimentally optimize novel nucleic acid payloads (single stranded and double stranded long and short DNA/RNA) for improved topology, activity and stability (through design and conjugation)
In vitro validate novel payloads in cell culture systems for efficacy and stability
Independently synthesize and interpret results and troubleshoot experiments
Be a scientific leader and partner for junior members in the team
Communicate progress and next steps within team and cross-functionally
Collaborate with colleagues across teams
Maintain electronic lab notebooks, write SOPs and tech transfer protocols when needed
Work independently and collaborate with scientific colleagues in support of team goals
Adhere to laboratory safety requirements and procedures
Qualifications
Ph.D. +0-1 year industry experience or BS with +8 years industry experience or MS with + 6 years industry experience.
Candidates must have hands-on experience in synthetic biology/ DNA vector design, cell culture, flow cytometry and general molecular biology tools (PCR/qPCR/ddPCR).
Experience with DNA origami highly desirable.
Experience with xNA conjugation and biophysical characterization a plus.
Experience working with different RNA modalities (siRNA, mRNA) a plus.
Experience with xNA purification (HPLC, FPLC) and pre-formulation a plus.
Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
Comfortable delivering against challenging commitments.
Self-motivated, execution-focused and adaptable to evolving project priorities and eager to learn new skills.
Equal Employment Opportunity Flagship Pioneering
and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies
do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Flagship Pioneering's companies is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Flagship Pioneering's companies, and they will not owe any referral or other fees with respect thereto.
Job details
Seniority level: Mid-Senior level
Employment type: Contract
Job function: Research, Analyst, and Information Technology
Industries: Retail
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This position focuses on designing and testing nucleic acid payloads for packaging within Anellovector VLPs as part of the Nucleic Acids Biochemistry team.
Position Summary Ring Therapeutics is seeking a Scientist I (contractor) to join the Nucleic Acids Biochemistry team within Platform to help design and test novel nucleic acid payloads for packaging within Anellovector VLPs. The ideal candidate will bring creativity to ideation, gap analysis, design and experimentation revolving around molecular biology and cell culture. We are searching for enthusiastic and highly motivated individuals who are comfortable multitasking and working both within a team and independently on various aspects of nucleic acids payloads within the context of viral vector packaging.
Key Responsibilities
End to end ideate, design and experimentally optimize novel nucleic acid payloads (single stranded and double stranded long and short DNA/RNA) for improved topology, activity and stability (through design and conjugation)
In vitro validate novel payloads in cell culture systems for efficacy and stability
Independently synthesize and interpret results and troubleshoot experiments
Be a scientific leader and partner for junior members in the team
Communicate progress and next steps within team and cross-functionally
Collaborate with colleagues across teams
Maintain electronic lab notebooks, write SOPs and tech transfer protocols when needed
Work independently and collaborate with scientific colleagues in support of team goals
Adhere to laboratory safety requirements and procedures
Qualifications
Ph.D. +0-1 year industry experience or BS with +8 years industry experience or MS with + 6 years industry experience.
Candidates must have hands-on experience in synthetic biology/ DNA vector design, cell culture, flow cytometry and general molecular biology tools (PCR/qPCR/ddPCR).
Experience with DNA origami highly desirable.
Experience with xNA conjugation and biophysical characterization a plus.
Experience working with different RNA modalities (siRNA, mRNA) a plus.
Experience with xNA purification (HPLC, FPLC) and pre-formulation a plus.
Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
Comfortable delivering against challenging commitments.
Self-motivated, execution-focused and adaptable to evolving project priorities and eager to learn new skills.
Equal Employment Opportunity Flagship Pioneering
and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies
do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Flagship Pioneering's companies is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Flagship Pioneering's companies, and they will not owe any referral or other fees with respect thereto.
Job details
Seniority level: Mid-Senior level
Employment type: Contract
Job function: Research, Analyst, and Information Technology
Industries: Retail
Referrals increase your chances of interviewing at Syracuse University Lubin House by 2x.
Get notified about new Scientist jobs in Cambridge, MA.
#J-18808-Ljbffr