Califesciences
Senior Scientist I (Machine Learning) - Biologics Cell Culture Development
Califesciences, South San Francisco, California, us, 94083
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.
Job Description The Biologics CMC Development team at AbbVie has a long and rich history of biolog development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing biologic therapies, such as monoclonal antibodies, bi-specifics and novel modalities, to human clinical studies and eventual licensure. This role will be imbedded in a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs.
This position is an onsite role in a lab-based function.
To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment with face-to-face cross-functional interactions between scientists.
In this position, you will perform cell culture process modeling, cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies.
Responsibilities
Develop, implement, refine, and validate machine learning (ML) models for predicting cell culture process performance
Communicate model findings and suggest experimental strategy and/or workflow improvements to support early- and late-stage development
Actively seek out opportunities to optimize our platform or enhance our understanding of cell culture processes using ML models and wet lab experiments
Design and execute scalable ambr250, 2L, 50L, 200L and 500L single use bioreactors processes
Represent the cell culture development group in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project deliverables and timelines
Publish or present scientific findings in peer-reviewed journals, internal or external conferences or consortia
Display effective organization, verbal written communication skills, and adherence to good documentation practices
Qualifications Basic Qualifications:
Scientific degree in computer science, statistics and applied mathematics, computational biology, bioinformatics, data science, chemical engineering, bioengineering, or a related field, with BS or equivalent education and 10+ years of experience, OR MS or equivalent education and 8+ years of experience, OR PhD and 0+ years of experience
Must have industry or research experience in developing, implementing, and validating ML models
Must have a strong understanding of statistical methods, ML methodologies, and ML frameworks (e.g., Sci-kit Learn, TensorFlow, PyTorch)
Must demonstrate programming competency for model implementation in Python equivalent
Must have experience in data visualization tools (e.g., Matplotlib, Plotly) to communicate model finding
Strong attention to detail; active and quick learner; able to change course quickly as needed; raises the bar and is never satisfied with the status quo; open to suggestions and embraces the ideas of others; collaborative actively builds relationships with others
Experienced in authoring peer-reviewed publications, technical reports, regulatory documents, and/or presentations at conferences
Proficient with Microsoft Office software and strong familiarity with statistical modelling software/tools (e.g., JMP, SIMCA, Minitab, Design Expert)
Preferred:
Prior experience in developing and implementing ML models for biological data is highly desirable
Experience in implementing transfer learning is highly desirable
Expertise in programming (e.g., Python, Javascript, C++)
Experience in CMC cell culture process development is highly desirable
Demonstrated scientific aptitude through authorship of peer-reviewed publications
Strong understanding of design of experiments (DOE)
Proficient in aseptic technique
Basic understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts
Experienced in developing and executing mammalian suspension cell culture processes in shake flasks, ambr250, and/or 2L bioreactors
Experienced in the tech transfer of cell culture and primary recovery processes to GMP manufacturing facilities in other locations
Experienced in authoring and reviewing technical reports, GMP campaign summary reports, and relevant sections in regulatory filings
Additional Information
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html
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Job Description The Biologics CMC Development team at AbbVie has a long and rich history of biolog development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing biologic therapies, such as monoclonal antibodies, bi-specifics and novel modalities, to human clinical studies and eventual licensure. This role will be imbedded in a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs.
This position is an onsite role in a lab-based function.
To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment with face-to-face cross-functional interactions between scientists.
In this position, you will perform cell culture process modeling, cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies.
Responsibilities
Develop, implement, refine, and validate machine learning (ML) models for predicting cell culture process performance
Communicate model findings and suggest experimental strategy and/or workflow improvements to support early- and late-stage development
Actively seek out opportunities to optimize our platform or enhance our understanding of cell culture processes using ML models and wet lab experiments
Design and execute scalable ambr250, 2L, 50L, 200L and 500L single use bioreactors processes
Represent the cell culture development group in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project deliverables and timelines
Publish or present scientific findings in peer-reviewed journals, internal or external conferences or consortia
Display effective organization, verbal written communication skills, and adherence to good documentation practices
Qualifications Basic Qualifications:
Scientific degree in computer science, statistics and applied mathematics, computational biology, bioinformatics, data science, chemical engineering, bioengineering, or a related field, with BS or equivalent education and 10+ years of experience, OR MS or equivalent education and 8+ years of experience, OR PhD and 0+ years of experience
Must have industry or research experience in developing, implementing, and validating ML models
Must have a strong understanding of statistical methods, ML methodologies, and ML frameworks (e.g., Sci-kit Learn, TensorFlow, PyTorch)
Must demonstrate programming competency for model implementation in Python equivalent
Must have experience in data visualization tools (e.g., Matplotlib, Plotly) to communicate model finding
Strong attention to detail; active and quick learner; able to change course quickly as needed; raises the bar and is never satisfied with the status quo; open to suggestions and embraces the ideas of others; collaborative actively builds relationships with others
Experienced in authoring peer-reviewed publications, technical reports, regulatory documents, and/or presentations at conferences
Proficient with Microsoft Office software and strong familiarity with statistical modelling software/tools (e.g., JMP, SIMCA, Minitab, Design Expert)
Preferred:
Prior experience in developing and implementing ML models for biological data is highly desirable
Experience in implementing transfer learning is highly desirable
Expertise in programming (e.g., Python, Javascript, C++)
Experience in CMC cell culture process development is highly desirable
Demonstrated scientific aptitude through authorship of peer-reviewed publications
Strong understanding of design of experiments (DOE)
Proficient in aseptic technique
Basic understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts
Experienced in developing and executing mammalian suspension cell culture processes in shake flasks, ambr250, and/or 2L bioreactors
Experienced in the tech transfer of cell culture and primary recovery processes to GMP manufacturing facilities in other locations
Experienced in authoring and reviewing technical reports, GMP campaign summary reports, and relevant sections in regulatory filings
Additional Information
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html
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