LanceSoft Inc
Scientist 2 - Research and Development
LanceSoft Inc, San Diego, California, United States, 92189
Overview
Title:
Scientist I, Oligonucleotide Analytics Location:
La Jolla, CA Duration:
09/15/2025 to 09/14/2026 (12 Months) Onsite:
100% onsite (no negotiations) Work Arrangement:
Must be able to commute to work every day Education:
PhD required Experience:
Must have experience with Analytical Chemistry, Oligonucleotides, and siRNA; previous gene therapy experience; 1-3 years of experience; experience with Chromatography (LC-MS); experience with Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS Description
Key Responsibilities
Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects Optimize methods and improve analytical capabilities for Client Oligonucleotide synthesis Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS. Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in-class analytical chemistry methodologies such as different column matrices for optimal siRNA characterization Support integrity confirmation requests (such as concentration) by assay development and biology teams Conduct QC for lipid nanoparticle (LNP) formulations of mRNA Ensure the supply of laboratory consumables and reagents are in stock as needed Maintain a high level of productivity in the laboratory setting. Present data and reports on project status at individual, group, and departmental meetings. Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Top Three Skills:
Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughput analytical capabilities Role is 100% onsite
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Title:
Scientist I, Oligonucleotide Analytics Location:
La Jolla, CA Duration:
09/15/2025 to 09/14/2026 (12 Months) Onsite:
100% onsite (no negotiations) Work Arrangement:
Must be able to commute to work every day Education:
PhD required Experience:
Must have experience with Analytical Chemistry, Oligonucleotides, and siRNA; previous gene therapy experience; 1-3 years of experience; experience with Chromatography (LC-MS); experience with Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS Description
Key Responsibilities
Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects Optimize methods and improve analytical capabilities for Client Oligonucleotide synthesis Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS. Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in-class analytical chemistry methodologies such as different column matrices for optimal siRNA characterization Support integrity confirmation requests (such as concentration) by assay development and biology teams Conduct QC for lipid nanoparticle (LNP) formulations of mRNA Ensure the supply of laboratory consumables and reagents are in stock as needed Maintain a high level of productivity in the laboratory setting. Present data and reports on project status at individual, group, and departmental meetings. Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Top Three Skills:
Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughput analytical capabilities Role is 100% onsite
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